Important Research Studies on Autism: the Foundation for the Cortica Care Model

The below research papers and studies helped shape the foundation for the Cortica Care Model. Topics include genetic and environmental causes of autism, neuroimaging and neural networks, neurophysiology, neurotransmitters, sleep, biochemistry/metabolism, immune, gastrointestinal, developmental therapies, language & communication, ABA, family & home, Transcutaneous Vagus Nerve Stimulation, and more.

Genetic and Environmental Causes of Autism

• Autism spectrum disorder genetics: diverse genes with diverse clinical outcomes

• A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder

• Prevalence of autism spectrum disorder phenomenology in genetic disorders: a systematic review and meta-analysis

• Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study

• Autism risk associated with parental age and with increasing difference in age between the parents

• Residential proximity to freeways and autism in the CHARGE study

• Epigenetics of autism spectrum disorders

• Neurobehavioural effects of developmental toxicity

• Genetic heterogeneity in autism: From single gene to a pathway perspective

Neuroimaging and Neural Networks

• Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here

• The nature of brain dysfunction in autism: functional brain imaging studies

• Imaging evidence for disturbances in multiple learning and memory systems in persons with autism spectrum disorders

• Enhanced visual processing contributes to matrix reasoning in autism

Neurophysiology

• The role of epilepsy and epileptiform EEGs in autism spectrum disorders

• Epilepsy and Autism

• Psychiatric and Behavioural Disorders in Children with Epilepsy (ILAE Task Force Report): Epilepsy and ADHD

• Predictive value of isolated epileptiform discharges for a favorable therapeutic response to antiepileptic drugs in nonepileptic psychiatric patients

• A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel

Neurotransmitters

• mGluR antagonists and GABA agonists as novel pharmacological agents for the treatment of autism spectrum disorders

Sleep

• Melatonin in autism spectrum disorders: a systematic review and meta-analysis

• Melatonin in autism spectrum disorders

• Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects

Biochemistry/Metabolism

• Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

• Mitochondrial dysfunction as a neurobiological subtype of autism spectrum disorder: evidence from brain imaging

• Relative carnitine deficiency in autism

• A prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disorders

• Reduced levels of plasma polyunsaturated fatty acids and serum carnitine in autistic children: relation to gastrointestinal manifestations

• Improvement of regressive autism symptoms in a child with TMLHE deficiency following carnitine supplementation

• Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy

• Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes

• Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups

• Cerebral folate receptor autoantibodies in autism spectrum disorder

• Cerebral folate deficiency with developmental delay, autism, and response to folinic acid

Immune

• Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference

• Antibody-mediated neuronal cell signaling in behavior and movement disorders

• Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin

• The role of immune dysfunction in the pathophysiology of autism

Gastrointestinal

• Sleep and gastrointestinal disturbances in autism spectrum disorder in children

• Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs

• Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report

• Colonization-induced host-gut microbial metabolic interaction

• Host-gut microbiota metabolic interactions

• Normal gut microbiota modulates brain development and behavior

• Autism spectrum disorders and intestinal microbiota

• Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified

• Potential Etiologic Factors of Microbiome Disruption in Autism

Developmental Therapies

• Sensory processing in autism: a review of neurophysiologic findings

• An exploration of sensory and movement differences from the perspective of individuals with autism

• Dyspraxia in autism: association with motor, social, and communicative deficits

• Evidence that the pattern of visuomotor sequence learning is altered in children with autism

• Motor persistence and inhibition in autism and ADHD

• Behavioural and neural basis of anomalous motor learning in children with autism

• Altered connectivity and action model formation in autism is autism

• Rhythm, movement, and autism: using rhythmic rehabilitation research as a model for autism

• Motor control and children with autism: deficit of anticipatory function?

• Music therapy for people with autism spectrum disorder

• Rhythmic auditory stimulation in rehabilitation of movement disorders: a review of current research

Language & Communication

• Hyperlexia in children with autism spectrum disorders

• Teaching non-verbal children with autistic disorder to read and write: a pilot study

ABA

• A systematic review of early intensive intervention for autism spectrum disorders

• Publication bias in studies of an applied behavior-analytic intervention: an initial analysis

• Perceptual learning in autism: over-specificity and possible remedies

• The intense world theory - a unifying theory of the neurobiology of autism

Family & Home

• Comparison of Siblings of Individuals with Autism and Siblings of Individuals with Other Diagnoses

• The adjustment of non-disabled siblings of children with autism

• Siblings of individuals with an autism spectrum disorder: sibling relationships and well being in adolescence and adulthood

• Psychosocial adjustment in siblings of children with autism

• Fatigue, wellbeing and parental self-efficacy in mothers of children with an autism spectrum disorder

• Maternal Mental Health After a Child’s Diagnosis of Autism Spectrum Disorder

• Diagnostic practice and its impacts on parental health and child behaviour problems in autism spectrum disorders

• Impact of Diagnostic Practices on the Self-Reported Health of Mothers of Recently Diagnosed Children with ASD

• Death concerns and psychological well-being in mothers of children with autism spectrum disorder

• The impact of autism services on mothers' psychological well being

• Parent Beliefs About the Causes of Learning and Developmental Problems Among Children With Autism Spectrum Disorder: Results From a National Survey

Transcutaneous Vagus Nerve Stimulation

• Transcutaneous Vagus Nerve Stimulation: A Promising Method for Treatment of Autism Spectrum Disorders

• Autistic spectrum disorder, epilepsy, and vagus nerve stimulation

• Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity

Historical

• Autistic disturbances of affective contact

• Behavioral treatment and normal educational and intellectual functioning in young autistic children

Research Studies by Cortica Co-Founder Dr. Goh

• Differences in Neural Activity when Processing Emotional Arousal and Valence in Autism Spectrum Disorders

• Mitochondrial dysfunction as a neurobiological subtype of autism spectrum disorder: evidence from brain imaging

• Teaching non-verbal children with autistic disorder to read and write: a pilot study

• Imaging evidence for disturbances in multiple learning and memory systems in persons with autism spectrum disorders

• Using the circumplex model of affect to study valence and arousal ratings of emotional faces by children and adults with autism spectrum disorders

• Cognitive ability changes and dynamics of cortical thickness development in healthy children and adolescents

• Presyrinx in children with Chiari malformations

• Neuroimaging Features in a Neonate With Rhizomelic Chondrodysplasia Punctat

• Genotype–phenotype correlations in tuberous sclerosis: Who and how to treat

• Anorexia Nervosa in a Child with Tuberous Sclerosis Complex

• Infantile spasms and intellectual outcomes in children with tuberous sclerosis complex

• Prognostic Significance of Tuber Count and Location in Tuberous Sclerosis Complex

• Subependymal giant cell tumors in tuberous sclerosis complex

*These research papers are intended to be used solely for informational and educational purposes only and that neither Cortica nor its healthcare providers necessarily endorse the findings or conclusions of this research.